At high doses, both enantiomers of methamphetamine can induce stereotypy and psychosis, but levomethamphetamine is less desired by drug abusers because of its weaker pharmacodynamic profile.
one-tenth) effects on striatal dopamine and shorter psychodynamic effects. D-methamphetamine is a stronger psychostimulant, but l-methamphetamine has a longer half-life and is CNS-active with weaker (approx. Methamphetamine is chiral, and thus occurs in two enantiomers (non-superimposable mirror images of each other): dextrorotary and levorotary.